RecruitingPhase 2NCT06421675

Outpatient and Intermittent Dosing of Elranatamab in Relapsed/Refractory Multiple Myeloma

A Study of Elranatamab Management With Outpatient and Intermittent Dosing in Relapsed/Refractory Multiple Myeloma


Sponsor

Ontario Clinical Oncology Group (OCOG)

Enrollment

40 participants

Start Date

Mar 28, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A phase II study of single agent elranatamab in patients with relapsed and/or refractory multiple myeloma (MM) who have previously received at least three classes of therapeutic agents and are refractory to the last line of treatment. The primary objective of this study is to improve the tolerability and safety of elranatamab in patients with relapsed and/or refractory multiple myeloma by evaluating an outpatient and intermittent dosing strategy.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether elranatamab — a drug that helps the immune system find and kill multiple myeloma cells — can be given less frequently and in an outpatient (clinic visit, not hospital) setting for people whose myeloma has come back or stopped responding to treatment. **You may be eligible if...** - You have multiple myeloma that has relapsed (come back) or is refractory (not responding) to prior treatments - You have received at least one prior treatment for myeloma - Your myeloma is measurable in blood, urine, or lab tests - You are in acceptable overall health **You may NOT be eligible if...** - You have never had myeloma treatment before - You have serious organ problems (heart, liver, kidneys) - You have active infections or certain other cancers - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGElranatamab injection

Elranatamab (Elrexfio) is a humanized bispecific antibody that targets both BCMA-expressing multiple myeloma (MM) cells and CD3-expressing T cells.


Locations(5)

Vancouver Cancer Center

Vancouver, British Columbia, Canada

Juravinski Cancer Center

Hamilton, Ontario, Canada

Kingston General Hospital

Kingston, Ontario, Canada

London Health Science Centre - Victoria Hospital

London, Ontario, Canada

Ottawa Hospital

Ottawa, Ontario, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06421675


Related Trials