RecruitingNCT06423768

fMRI in CardiaC arrEst With Uncertain Prognosis

The fMRI in CardiaC arrEst With Uncertain Prognosis (FACE-UP) Study


Sponsor

Brigham and Women's Hospital

Enrollment

50 participants

Start Date

May 16, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to determine whether specific advanced MRI measures are associated with functional outcomes in patients who are comatose after cardiac arrest. The main question\[s\] it aims to answer are: Aim 1: Determine if stimulus-based functional MRI (fMRI)-measured activations are independently associated with favorable neurological outcomes after cardiac arrest Aim 2: Determine if resting state functional MRI (rs-fMRI)-measured functional network connectivity is independently associated with favorable neurological outcomes after cardiac arrest. Aim 3: Determine if diffusion tensor imaging (DTI)-measured white matter integrity is associated with favorable neurological outcomes after cardiac arrest. Participants will undergo advanced MRI sequences at time of clinical MRI, and will be followed for 6 months post-arrest.


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • survive of an in or out of hospital cardiac arrest

Exclusion Criteria8

  • Drug overdose
  • Opinion of medical team patient unlikely to survive more than 24 hours (severe concurrent medical illness, dilated and unreactive pupils, etc..)
  • Following verbal commands (MD or RN note) once TTM is complete and normothermia is achieved (Day 2 or 3; Day of admission is Hospital Day 0). If no TTM is administered, this can be assessed on Hospital Day 2.
  • Following verbal commands (study team assessment) at time of MRI
  • Family planning to WLST at time of enrollment
  • Non English speaker (okay if English not primary language, as long as they can understand it)
  • Permanent Contraindication to MRI (some kind of implanted metal)
  • Pregnant

Interested in this trial?

Get notified about updates and connect with the research team.


Locations(2)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Brigham and Women's Hospital

Brookline, Massachusetts, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06423768


Related Trials