RecruitingNot ApplicableNCT06426693

Craving Network Neurofeedback

Connectome-based Neurofeedback of the Craving Network to Reduce Food Cue Reactivity


Sponsor

Yale University

Enrollment

50 participants

Start Date

Nov 27, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This project tests whether individuals with overweight or obesity and high craving can learn to change their brain response to food cues using neurofeedback, to impact their craving and eating behavior.


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria3

  • Ages 18 to 60 years
  • Body mass index >25 kg/m2
  • >2.37 Food Craving Inventory score

Exclusion Criteria7

  • Current or past 6 months use of anti-obesity medications
  • Weight-reduced state defined as >10% weight reduction in the past 6 months.
  • Nicotine use
  • Current diagnosis of neurological or psychiatric disorder
  • Obesity-related diseases such as type-2 diabetes
  • Contraindications to MRI
  • Baseline scanning with motion >0.15mm frame to frame displacement.

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Interventions

DEVICEExperimental feedback

Participants provided with feedback of target brain activation patterns (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).

DEVICEControl feedback

Participants provided with control (sham, yoked to another participant) feedback (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).


Locations(1)

Yale MRRC Anlyan Center

New Haven, Connecticut, United States

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NCT06426693


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