Longitudinal Study of Gene Expression in the Human Placenta During First-trimester and Full-term Pregnancy at the Single Cell Level
Cellular Transcriptomic Trajectory of the Human Placenta During Pregnancy
Assistance Publique - Hôpitaux de Paris
100 participants
Mar 25, 2026
OBSERVATIONAL
Conditions
Summary
The single nucleus RNA-seq approach allows the placental transcriptome to be analyzed from nuclei, thus preserving the integrity of placental syncytium. This approach is feasible on small fragments of villi and offers for the first time the possibility to consider the characterization of gene expression within the structural unit of the human placenta during pregnancy (at the 1st trimester and childbirth)
Eligibility
Inclusion Criteria4
- Age 18 to 50
- Progressive monofoetal pregnancy between 11 and 15 weeks of amenorrhea
- Patient with prenatal medical indication and requesting chorionic villus biopsy with cytogenetic analysis or molecular genetics
- Patient scheduled for delivery at Port-Royal Maternity Hospital
Exclusion Criteria5
- Minor patient
- Multiple pregnancy
- Patient's objection
- Without health insurance
- Patient under guardianship or curatorship
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Interventions
Placental transcriptomic analysis
Locations(1)
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NCT06427408