Adjuvant Chemoradiotherapy Versus Chemotherapy for Pancreatic Cancer (ADJUPANC)

This study is comparing two treatment approaches after surgery for pancreatic cancer: chemotherapy combined with radiation (chemoradiotherapy) versus chemotherapy alone. Researchers want to find out which approach works better at preventing the cancer from coming back in patients whose surgery showed high-risk features. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with pancreatic duct cancer (confirmed by tissue biopsy) - Your surgery showed high-risk features — such as cancer spread to lymph nodes, incomplete removal of the tumor, or cancer spreading into nearby blood or lymph vessels - You have not yet received any cancer treatment after surgery - Imaging shows no signs of cancer coming back - You are in generally good health and able to care for yourself (ECOG 0–1) - Your blood counts, liver function, and kidney function are within acceptable ranges **You may NOT be eligible if...** - You have already received any cancer treatment after surgery - You have had another type of cancer within the past 5 years - Imaging shows the cancer has returned or spread - You are in poor health or have limited ability to care for yourself - You have active inflammatory bowel disease or recent bowel bleeding - You are pregnant or breastfeeding - You have significant heart or breathing problems Talk to your doctor to see if this trial is right for you.