Central-boost Ablative Radiation Therapy for Solid Tumors (CBART)

This study is testing a new type of radiation therapy called Central-boost Ablative Radiation Therapy (CBART) for solid tumors in the lung, liver, pancreas, or abdomen. The technique delivers a high-dose boost to the center of the tumor to destroy it more effectively while trying to protect nearby healthy organs. **You may be eligible if...** - You are between 18 and 75 years old - You have a confirmed malignant tumor in your lung, liver, pancreas, or abdomen - If your cancer has spread, it has spread to only a limited number of spots (oligometastasis) - Your tumor is large enough (at least 2 cm) or is very close to sensitive organs - You are in generally good health (ECOG 0–1) - Your blood counts, liver, and kidney function are within normal ranges **You may NOT be eligible if...** - This tumor has already been treated with radiation - You have had any cancer in the past 5 years - You are in poor health or have limited ability to care for yourself - You have active inflammatory bowel disease (for pancreas or abdominal tumors) - You have had bowel bleeding or perforation in the last 6 months - You have an active infection requiring antibiotics - You have significant heart or breathing problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.