The Impact of Probiotic on Survival and Treatment Response in Metastatic Non-small Cell Lung Cancer Patients

This study is looking at whether taking a daily probiotic supplement can help improve survival and treatment outcomes in people with stage IV (metastatic) non-small cell lung cancer. The gut microbiome may influence how the immune system responds to cancer treatments, and this trial aims to explore that connection. **You may be eligible if...** - You are over 18 years old - You have been confirmed to have non-small cell lung cancer (NSCLC) - Your cancer is in an advanced or metastatic stage (Stage IV) - You are healthy enough to be up and about for most of the day (ECOG less than 2) - Your blood counts (white cells, neutrophils, and platelets) are at acceptable levels **You may NOT be eligible if...** - You have previously been treated with certain immunotherapy drugs (anti-PD-1, anti-PD-L1, anti-CTLA-4 or related agents) - You are currently taking probiotic supplements or consuming probiotic yogurt - You have taken antibiotics in the past month - You have active interstitial lung disease or a history of it requiring steroids - You need regular high-dose steroids or immunosuppressants - You have severe heart failure or a history of myocarditis (heart inflammation) - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.