Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury(Metric-TBI)
Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury: a Prospective, Multicenter, Observational Cohort Study
Beijing Tiantan Hospital
2,000 participants
Aug 1, 2024
OBSERVATIONAL
Conditions
Summary
A prospective, multicenter, observational cohort study is designed to compare the effectiveness of intervention in multi-grade hospitals for acute traumatic brain injury and to optimize clinical outcomes.
Eligibility
Inclusion Criteria3
- Patient (1 years to 89 years) presenting with clinical symptoms of traumatic brain injury
- Traumatic brain injury verified on cranial computed tomography or magnetic resonance imaging
- Written informed consent from patients or their next of kin according to the patient's cognitive status
Exclusion Criteria5
- patients ≥90 years of age
- patients who did not accept follow-up visits or were unable to complete follow-up assessments
- patients with incomplete information
- patients who did not obtain written informed consent
- patients with concomitant cancer or other serious illnesses
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Interventions
Neurological function will be examined using Glasgow Coma Scale (GCS) and Extended Glasgow Outcome Scale (GOSE).The GOSE was created as an advancement from the original GOS. The GOSE score categorizes the prognosis of patients with traumatic brain injury into eight categories.The 8 categories are: Dead, Vegetative State, Lower Severe Disability, Upper Severe Disability, Lower Moderate Disability, Upper Moderate Disability, Lower Good Recovery, and Upper Good Recovery.
Mental State, cognitive function, and life quality will be examined using the Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9(PHQ-9), Rivermead post-concussion symptoms questionnaire(RPQ), PTSD Checklist-5 Version(PCL-5)，Six-Item Screener（SIS） and 12-Item Short-Form Health Survey version 2(SF-12v2).
Collect peripheral blood samples from patients.
Collect hematoma fluid, dura mater, and hematoma outer membrane samples from patients.
Locations(64)
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NCT06429774