RecruitingPhase 3NCT06430112

Liposomal Bupivacaine vs Ropivacaine for TAPBs

Liposomal Bupivacaine vs Ropivacaine for Ultrasound-guided Transversus Abdominis Plane Blocks in Laparoscopic Lower Abdominal Tumor Resection: A Prospective Randomized Trial

Sponsor

Sun Yat-sen University

Enrollment

74 participants

Start Date

Nov 1, 2023

Study Type

INTERVENTIONAL

Conditions

Abdominal Tumor

Summary

Few studies have compared the efficacy of ultrasound (US)-guided TAP blocks with Liposomal bupivacaine(LB) versus ropivacaine in reducing postoperative opioid usage in patients undergoing laparoscopic lower abdominal tumor Resection. Therefore, we are conducting this prospective, randomized controlled trial to compare the postoperative analgesic effects of LB and ropivacaine for TAP blocks among patients undergoing laparoscopic colorectal procedures.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria3

Patients undergoing laparoscopic resection of lower abdominal tumors
ASA grade II-III
Age: 18-70 years.

Exclusion Criteria11

(1) The patient does not agree to participate in the clinical study
(2) The patient has a clear history of opioid tolerance or allergy
(3) The patient has a history of local anesthetic allergy
(4) Previous history of dementia, mental illness or other central nervous system diseases
(5) Have a history of chronic pain or are taking opioids and other analgesics
(6) Patients are generally in poor condition with a history of serious diseases of cardiovascular system, respiratory system, digestive system, urinary system or central nervous system, and may not survive for more than 3 months
(7) The patient had any of the following conditions in the 12 months before surgery: myocardial infarction, severe/unstable angina pectoris, coronary artery bypass grafting, congestive heart failure, cerebrovascular accident, pulmonary embolism
(8) Pregnant women
(9) Unable to cooperate with follow-up or poor compliance
(10) Patients with acute myocardial infarction, cardiac arrest or shock during surgery or hospitalization
(11) ASA score above grade III.

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Interventions

DRUGLiposomal Bupivacaine

After induction of anesthesia, bilateral TAPB was performed under ultrasound guidance. The patients in the bupivacaine liposome group were injected with bupivacaine liposome 133mg(10ml+ 10ml 0.9% normal saline mixed into 20ml)/ point (two points in total).

DRUGRopivacaine

Patients in ropivacaine group were given 0.25% ropivacaine 20ml/ point (two points in total).

Locations(1)

Jingdun Xie

Guangzhou, Guangdong, China

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NCT06430112