Study of Metabolic, Transcriptomic and Proteomic Characteristics in Relapsed Glioblastoma

This study is an observational research project analyzing tumor tissue samples — stored from past surgeries — from people who had surgery for glioblastoma (an aggressive brain tumor) both the first time and at recurrence. Researchers will look at genetic, protein, and metabolic characteristics of the tumors to understand why glioblastoma comes back and becomes resistant to treatment. **You may be eligible if...** - You are over 18 years old - You had surgery for primary (first-time) glioblastoma AND recurrent glioblastoma between 2005 and 2023 at the Bordeaux University Hospital (CHU de Bordeaux) **You may NOT be eligible if...** - You received systemic therapy (such as chemotherapy or targeted therapy) for a different, non-glioblastoma tumor Talk to your doctor to see if this trial is right for you.