RecruitingNCT06431009

The Danish Region Midt Schizophrenia Cohort

The Danish Region Midt Schizophrenia (RMS) Cohort: Representative Cohort of Patients With a First-episode Schizophrenia Spectrum Disorder With Long-term Follow-up

Sponsor

University of Aarhus

Enrollment

350 participants

Start Date

Feb 20, 2024

Study Type

OBSERVATIONAL

Conditions

Schizophrenia

Summary

The objective of this study is to recruit patients at the first diagnosis with a schizophrenia spectrum disorder (SSD) and ultra-high risk patients (UHR), defined as patients with drug abuse and psychotic symptoms indicating a risk for developing schizophrenia. Thereby, the investigators aim to establish a large representative cohort of patients with a first-episode SSD or patients at UHR, enabling investigations of the etiology and long-term prognosis of SSDs. The primary aim is to learn more about the importance of adverse childhood experiences (ACEs) and the immune system in the etiology and course of schizophrenia. Patients will be followed with planned visits after 1, 2, 3, 12 and 24 months including online questionnaires after 2, 6, 10 and 26 weeks. There will be the possibility to contact patients again for subsequent follow-up visits.

Eligibility

Min Age: 15 Years

Plain Language Summary

Simplified for easier understanding

This study is building a long-term database of people in Denmark who have recently been diagnosed with their first episode of schizophrenia or a related psychotic disorder, or who are considered at high risk of developing one. The goal is to better understand these conditions over time. **You may be eligible if...** - You are 15 years of age or older - You have been diagnosed within the past 3 months with a first episode of schizophrenia or related psychotic disorder (ICD-10: F20-29), OR you have been identified as at ultra-high risk (UHR) for psychosis (ICD-10: F1X.5) - You are able to give informed consent, both verbally and in writing **You may NOT be eligible if...** - You are currently subject to any coercive psychiatric measure (including forensic psychiatry settings) - Your treating doctor determines that your clinical condition prevents you from safely taking part in the research study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERTreatment-as-usual

Patients will be treated and followed according to normal clinical treatment guidelines at the local psychiatric hospitals, which will not be affected by participation in the RMS cohort.