RecruitingEarly Phase 1NCT06431529

A Study of Tumor Neoantigen-specific T Cells in the Treatment of Advanced Solid Tumors

Exploratory Clinical Study of Tumor Neoantigen-specific T Cells in the Treatment of Advanced Solid Tumors


Sponsor

JIANG LONGWEI

Enrollment

6 participants

Start Date

Apr 18, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if tumor neoantigen-specific T cells can treat patients with advanced solid tumors. The main questions it aims to answer are: Evaluate the safety of intravenous infusion of tumor neoantigen-specific T cells in the treatment of advanced solid tumors such as ovarian cancer, non-small cell lung cancer, and colorectal cancer. To evaluate the effectiveness of intravenous infusion of tumor neoantigen-specific T cells in the treatment of advanced solid tumors such as ovarian cancer, non-small cell lung cancer, and colorectal cancer and to study its immunological properties in patients.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized T-cell therapy — immune cells that are grown in a lab and trained to recognize your specific tumor's unique markers — in people with advanced solid tumors like ovarian cancer, lung cancer, or colon cancer. **You may be eligible if...** - You are between 18 and 75 years old - You have a solid tumor (such as ovarian cancer, non-small cell lung cancer, or colorectal cancer) confirmed by biopsy or lab test - Standard cancer treatments have failed or you have declined further chemotherapy - Your expected survival is more than 3 months - Your general health is reasonably good (ECOG score 0–2) - You are willing and able to use contraception during the study if you are of childbearing age **You may NOT be eligible if...** - You have received any form of immunotherapy in the past 3 months - You have serious infections, autoimmune disease, or significant organ problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALtumor neoantigen specific T cell

Isolate the patient's autologous monocytes, induce and culture them into tumor antigen presenting cells in vitro, and then phagocytose tumor tissue cells obtained from biopsy or surgery to present tumor neoantigens to autologous T cells. The final product For tumor neoantigen specific T cells (NeoT).


Locations(1)

Nanjing Jinling Hospital

Nanjing, Jiangsu, China

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NCT06431529


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