RecruitingPhase 1NCT06435910

Engineered Dendritic Cell Vaccines for Multiple Myeloma

Engineered Dendritic Cell Vaccines for Remission Maintenance in Multiple Myeloma Patients


Sponsor

Shenzhen Geno-Immune Medical Institute

Enrollment

10 participants

Start Date

May 11, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to determine the feasibility, safety, and efficacy of dendritic cell (DC) vaccines in the treatment of multiple myeloma (MM) or plasmacytoma based on immune-modified DC vaccines (DCvac). This approach is aimed to achieve prolonged maintenance of remission in multiple myeloma or plasmacytoma patients.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests a personalized vaccine made from a patient's own immune cells (called dendritic cells) that are engineered in the lab to help the immune system fight multiple myeloma — a cancer of the blood plasma cells. **You may be eligible if...** - You have been diagnosed with multiple myeloma or a related tumor called plasmacytoma - Your cancer is in a very good partial remission or complete remission after prior treatment - Your expected survival is more than 12 weeks - You have adequate veins for blood draws or a blood collection procedure (apheresis) - You are willing to give informed consent and attend follow-up visits **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have an active, uncontrolled infection - You have HIV or active hepatitis B or C - You are on ongoing systemic (whole-body) steroid medications (inhaled steroids are okay) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALDC vaccines

Antigen-presenting and immune modifying DCvacs to treat MM


Locations(2)

Shenzhen Geno-immune Medical Institute

Shenzhen, Guangdong, China

The Regional Hematology Center in Clinical Hospital No. 2 of the Ministry of Health

Vladivostok, Russia

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NCT06435910