RecruitingPhase 2NCT06436612

Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)

Phase II Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)


Sponsor

Jonsson Comprehensive Cancer Center

Enrollment

20 participants

Start Date

May 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Recent advances in radiation treatment have allowed for higher doses per treatment to be delivered safely. This study plans to use an MRI-guided linear accelerator to deliver the radiation treatment to ensure that the radiation dose is administered to the cancerous tumor, not the vital body organs. Potential participants with a sarcoma diagnosis will be referred to Radiation Oncology during this study. If the participant is interested in participating in this study, s/he receives radiation treatment daily for 5 consecutive days except for weekends and holidays. Within 12 weeks of completing the radiation therapy, the participant will have the primary tumor surgically removed. The radiation oncology team will follow the patients for 5 years after completing radiation therapy.


Eligibility

Min Age: 12 Years

Plain Language Summary

Simplified for easier understanding

This study (called the MARS Trial) tests a specialized type of targeted radiation treatment called Stereotactic Body Radiation Therapy (SBRT), guided by MRI and CT scans, to precisely treat sarcomas (rare soft tissue or bone cancers) in the abdomen or pelvis before surgery. **You may be eligible if...** - You have been diagnosed with sarcoma (confirmed by biopsy) that involves the abdomen or pelvis - Your cancer is either a new case or has come back (recurrent) - Your tumor can be surgically removed - You are 12 years or older - You are in reasonably good health (able to perform basic daily activities) - If you are a woman who could become pregnant, you must have a negative pregnancy test **You may NOT be eligible if...** - You are actively being treated for a separate cancer - The area to be treated has already received radiation in the past Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONMagnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy

stereotactic body radiation therapy (SBRT) administered over 5 days x 5.0 - 6.0 Gy for patients with abdominopelvic sarcomas.


Locations(1)

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, United States

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NCT06436612