RecruitingNCT06438705

99mTc Labeled FAP Targeted Molecular Probe in Early Diagnosis of Tumors

Clinical Application of a Novel 99mTc Labeled Fibroblast Activating Protein (FAP) Targeted Molecular Probe in Early Diagnosis of Tumors


Sponsor

Nanjing First Hospital, Nanjing Medical University

Enrollment

20 participants

Start Date

Jun 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

At present, radiopharmaceuticals targeting FAP have been developed for the diagnosis and treatment of various tumors. Considering the problems of fast tumor tissue clearance and short retention time in small molecule FAP inhibitors based on quinoline rings, this project optimized their ligands and developed a new FAP targeted technetium labeled molecular imaging probe for SPECT/CT imaging research to evaluate its safety in clinical application and its effectiveness in tumor diagnosis.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study tests a new radioactive imaging probe labeled with technetium (99mTc) that targets a protein called FAP (fibroblast activation protein), found in high amounts around many types of tumors. The study aims to see whether this new scan can detect tumors earlier and more accurately than existing imaging methods. **You may be eligible if...** - You are between 18 and 75 years old - An imaging test has found a suspected tumor - You are scheduled for surgery or a biopsy to confirm the diagnosis - Your kidney and liver function, blood counts, and other lab values meet the study requirements **You may NOT be eligible if...** - You have a known allergy to similar drugs or a history of severe allergic reactions - You have active hepatitis C, active hepatitis B, or another serious chronic infection - You have significantly impaired liver or kidney function - Your cancer makes up more than 50% of your body or is pressing on your spinal cord - Your expected survival is less than 6 months - You have received chemotherapy within the past 6 months - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTSPECT-CT imaging

The subjects were intravenously injected with 99mTc labeled FAPI imaging agent, and drank 300-500ml of water after administration. SPECT-CT imaging was performed 60 minutes later


Locations(1)

Nanjing First Hospital

Nanjing, Jiangsu, China

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NCT06438705


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