RecruitingNot ApplicableNCT06439355

Single-center Study of Gustation in Idiopathic Parkinson's Disease and Lewy Body Disease Using Gustatory Evoked Potential Analysis

Sponsor

Centre Hospitalier Universitaire Dijon

Enrollment

66 participants

Start Date

May 27, 2024

Study Type

INTERVENTIONAL

Conditions

Idiopathic Parkinson's Disease and Lewy Body Disease

Summary

The aim of the PI-PEG study is to explore the taste functions of the following 3 groups of participants: * healthy volunteers * patients with early Parkinson's disease * patients with incipient Lewy body disease. To this end, the results obtained from taste evoked potentials in each of the 3 groups of participants will be compared with each other and with different nutritional, motor and cognitive data. This study could reveal a difference in cortical processing of gustatory sensory information between patients who have had idiopathic Parkinson's disease progressing for 3 years or less, and patients who have had Lewy body disease progressing for 3 years or less. Indeed, a modification of taste evoked potentials (in terms of latencies) proportional to the degree of cerebral degeneration could be observed.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study examines taste (gustation) in patients with Parkinson's disease and Lewy body dementia — two conditions caused by abnormal protein buildup in the brain — using a test called Gustatory Evoked Potential (PEG) that measures how the brain responds to taste stimuli. Researchers hope this could help identify these diseases earlier. **You may be eligible if (patients)...** - You are an adult with a confirmed or probable diagnosis of Parkinson's disease or Lewy body dementia - You have fasted for at least 2 hours before testing - Your BMI is below 30 **You may NOT be eligible if...** - You are not covered by national health insurance - You are under legal guardianship - You are pregnant or breastfeeding - You score very low on cognitive tests (MMSE < 15 or MoCA < 10) - You had COVID-19 in the past 6 months - You are an active smoker (more than 4 cigarettes per day) - You have a pacemaker - You have diabetes (Type 1 or 2) - You are taking medications known to affect your sense of taste Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALFasting blood test

metabolic assays determination of food intake hormones oxidative stress and neurodegeneration marker assays

OTHERSubject interview

socio-demographic data, medical and family history, treatment taken

OTHERMotor assessment

MDS-UPDRS scale PART III

OTHERNeurocognitive assessment

MoCA and MMSE scales

OTHERNutritional assessment

anthropometric data (weight, height, BMI, waist circumference, hip circumference, android/gynoid ratio, triceps skin fold, brachial circumference), bioelectrical impedancemetry (fat mass, lean mass, water mass and bone mass)

OTHERTaste tests

Recording of PEGs in response to a sucrose solution and a free fatty acid solution (prepared beforehand)

Locations(1)

Chu Dijon Bourgogne

Dijon, France

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NCT06439355