Exploration of Therapeutic Strategies for NeoRAS Wild-type Metastatic Colorectal Cancer Based on Circulating Tumor DNA

This study explores a strategy for treating metastatic colorectal cancer (bowel cancer that has spread) that initially had a RAS gene mutation, but where the mutation has disappeared — a phenomenon called 'NeoRAS wild-type'. Researchers will use blood-based DNA tests to find these patients and guide treatment. **You may be eligible if...** - You have metastatic colorectal cancer that was originally confirmed to have a RAS mutation in tissue testing - You are in good physical condition (ECOG 0–1, meaning you can carry out daily activities with little limitation) - You are willing to provide blood samples and, if needed, tissue samples **You may NOT be eligible if...** - Your cancer does not show the NeoRAS wild-type pattern on testing - You are not well enough to continue treatment - You cannot provide the required samples Talk to your doctor to see if this trial is right for you.