Real-world Study to Evaluate the Efficacy and Safety of Liposome Irinotecan

This real-world study tracks how well liposome irinotecan (a chemotherapy drug with a special fat-based coating that helps deliver it into tumor cells) works for people with metastatic colorectal cancer or pancreatic cancer that has stopped responding to earlier treatments. **You may be eligible if...** - You have confirmed colorectal cancer (bowel cancer) or pancreatic cancer that has spread (metastatic disease) - Your cancer has stopped responding to standard first or second-line chemotherapy - You are being treated with liposome irinotecan as part of your regular care **You may NOT be eligible if...** - You have already received irinotecan or liposome irinotecan as a prior treatment - You have certain types of colorectal cancer that are not included in the study (e.g., MSI-high/MMR-deficient) - You have serious organ dysfunction that would prevent safe treatment Talk to your doctor to see if this trial is right for you.