RecruitingPhase 2NCT06446765

Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

Mindfulness-based Neurofeedback to Augment Dialectical Behavior Therapy (DBT) for Adults With Borderline Personality Disorder (Aim 1)


Sponsor

Yale University

Enrollment

150 participants

Start Date

Mar 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Inclusion Criteria5

  • age 18-60,
  • be able to provide written informed consent,
  • meet criteria for BPD on semi-structured clinical interview,
  • able to plan to keep any prescribed medications and psychotherapy constant during the study
  • fluent in English.

Exclusion Criteria15

  • current DBT psychotherapy outside the study
  • lifetime primary psychotic disorder or Bipolar I disorder
  • developmental disorder (e.g. autism)
  • history of learning disorder
  • moderate or severe substance use disorder in the last 6 months
  • active suicidal ideation with intent or plan in the past 3 months
  • history of major medical or neurologic disorder
  • MRI contraindications, including pregnancy
  • poor performance on reading task (WRAT \> 11 errors)
  • newly prescribed medications in the past 8 weeks
  • daytime sedating medications (e.g. benzodiazepines, opiates, sedating neuroleptics)
  • any scheduled daily benzodiazepines
  • change in psychotherapy type or frequency in the past 12 weeks.
  • At the discretion of the study PI
  • Eligibility will be determined by study personnel.

Interventions

BEHAVIORALmindfulness-based Neurofeedback

Participants will complete one session of mindfulness-based fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.

OTHERcontrol Neurofeedback

Participants will complete one session of control fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.


Locations(1)

Connecticut Mental Health Center

New Haven, Connecticut, United States

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NCT06446765


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