RecruitingPhase 2NCT06446765

Mindfulness-based Neurofeedback to Augment Psychotherapy for Adults With Borderline Personality Disorder

Mindfulness-based Neurofeedback to Augment Dialectical Behavior Therapy (DBT) for Adults With Borderline Personality Disorder (Aim 1)


Sponsor

Yale University

Enrollment

150 participants

Start Date

Mar 13, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to test the ability of mindfulness-based real time functional magnetic resonance imaging (fMRI) neurofeedback (mbNF) to increase the benefits of evidence-based psychotherapy for adults with Borderline Personality Disorder (BPD).


Eligibility

Min Age: 18 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether mindfulness-based neurofeedback — a technique where participants learn to regulate their own brain activity in real time using brain scans, combined with mindfulness practice — can enhance the effects of psychotherapy in adults with borderline personality disorder (BPD). **You may be eligible if...** - You are between 18 and 60 years old - You have been diagnosed with BPD based on a structured clinical interview - You are fluent in English - Your medications and psychotherapy have been stable for at least 8–12 weeks **You may NOT be eligible if...** - You are currently in DBT (dialectical behavior therapy) psychotherapy outside of this study - You have a lifetime history of a primary psychotic disorder or Bipolar I disorder - You have a developmental disorder or learning disorder - You have moderate or severe substance use disorder in the last 6 months - You have active suicidal ideation with intent or plan in the past 3 months - You have MRI contraindications (including pregnancy) or are on sedating medications Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALmindfulness-based Neurofeedback

Participants will complete one session of mindfulness-based fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.

OTHERcontrol Neurofeedback

Participants will complete one session of control fMRI neurofeedback prior to 20 weeks of remote online weekly DBT skills group.


Locations(1)

Connecticut Mental Health Center

New Haven, Connecticut, United States

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NCT06446765


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