A Study on the Correlation Between Cotinine Levels and Aneurysm Wall Enhancement on HRMRI.
A Prospective Cohort Study on the Correlation Between Patient Cotinine Levels and Intracranial Unruptured Aneurysm Wall Enhancement Based on High-resolution Magnetic Resonance Imaging
Zhujiang Hospital
450 participants
Sep 1, 2022
OBSERVATIONAL
Conditions
Summary
This study aims to collect clinical, laboratory, and imaging data from patients with unruptured intracranial aneurysms, and collect blood or urine samples for cotinine testing. The enrolled patients underwent high-resolution magnetic resonance angiography to detect whether the intracranial aneurysm wall was enhanced and classify the degree of enhancement. The purpose is to study the correlation between arterial aneurysm wall enhancement and cotinine levels
Eligibility
Inclusion Criteria5
- Age 18-75 years old, male or infertile female;
- Diagnosed as IA (intracranial aneurysm) through CTA, MRA, or DSA; And it is suitable for endovascular intervention treatment
- The patient and/or their legal representative or guardian fully understand the research purpose, voluntarily participate and sign informed consent Books;
- Patients willing to cooperate with high-resolution magnetic resonance imaging.
- Patients willing to follow up and evaluate according to clinical research protocol requirements
Exclusion Criteria8
- AVM (arteriovenous malformation), Moyamoya disease, or DAVF (dural arteriovenous fistula) related aneurysms;
- Patients with contraindications for high-resolution magnetic resonance imaging;
- Participants in clinical trials of other drugs or medical devices;
- Patients with severe underlying diseases and extremely poor clinical conditions who cannot tolerate general anesthesia surgery;
- Patients with poor compliance and inability to cooperate with follow-up;
- Possible or clear history of severe allergy to contrast agents;
- Patients with a life expectancy of less than 2 years;
- Women who are breastfeeding and preparing for pregnancy during the study period
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
cotinine detection
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06447714