RecruitingNCT06448468

Analysis of Ocular Surface Microbiota in Dry Eye Patients After Femtosecond Laser-assisted In-situ Keratomileusis (FS-LASIK)

Sponsor

Second Affiliated Hospital of Nanchang University

Enrollment

200 participants

Start Date

May 1, 2024

Study Type

OBSERVATIONAL

Conditions

Refractive Surgery

Summary

By using 16S rRNA sequencing technology to analyze the changes in ocular surface microbiota before and after surgery, as well as the impact of changes in ocular surface microbiota on FS-LASIK induced DES, new treatment ideas are provided for corneal FS-LASIK induced DES patients, and the incidence of FS-LASIK related DES is reduced.

Eligibility

Min Age: 18 YearsMax Age: 45 Years

Inclusion Criteria4

Age ≥ 18 years old;
Stable refractive index (refractive index change less than 0.5D in the past 2 years);
The best corrected far vision (CDVA) is 1.0 or better;
Postoperative dry eye patients need to meet the following criteria: Patient's Eye Surface Disease Index (OSDI) ≥ 13 and two of the following three criteria are met: Tear film rupture time (BUT) ≤ 10S Schirmer I test (mm/5min) ≤ 10mm, corneal fluorescein sodium staining exceeding 5 spots;

Exclusion Criteria5

History of eye trauma or surgery;
Suspected keratoconus;
Previously suffering from other eye diseases such as keratitis or edema, glaucoma, uveitis, retinal detachment, macular degeneration, cataracts, amblyopia, etc.;
Preoperative history of severe dry eye disease;
Patients with systemic diseases, such as hyperthyroidism or autoimmune diseases; Or severe mental disorders, such as anxiety and depression;

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