RecruitingPhase 2NCT06450873

Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery

A Phase 2 Pilot Window of Opportunity Study Turkey Tail Mushrooms (TTM) (Trametes Versicolor) in Post-Menopausal Women With HER2 (-) ER (+) Breast Cancer Planning to Undergo Surgical Therapy

Sponsor

Mayo Clinic

Enrollment

40 participants

Start Date

Oct 25, 2024

Study Type

INTERVENTIONAL

Conditions

Estrogen Receptor-Positive Breast Carcinoma HER2-Negative Breast Carcinoma

Summary

This phase II trial tests how well turkey tail mushroom (TTM) works in treating post-menopausal women with HER2-negative, estrogen receptor (ER)-positive breast cancer undergoing surgery. TTM is a common mushroom. In traditional Chinese medicine, it is used for enhancing function and removing toxins, as well as for cancer, hepatitis, and infections. There is previous evidence of significant tumor shrinkage occurring in the 2-month window between diagnosis and surgery in women who have taken TTM. Giving TTM may be effective in treating post-menopausal women with HER2-negative, ER-positive breast cancer undergoing surgery.

Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial tests whether taking turkey tail mushroom (Trametes versicolor) supplement before breast surgery can reduce cancer cell activity (measured by Ki-67, a marker of how fast cancer cells are dividing) in post-menopausal women with early-stage hormone receptor-positive, HER2-negative breast cancer. **You may be eligible if...** - You are a woman aged 18 or older and post-menopausal - You have been newly diagnosed with ER-positive, HER2-negative breast cancer with a Ki-67 ≥10% - Your tumor is detectable on mammogram or ultrasound (greater than 5mm) - You are scheduled for definitive breast surgery **You may NOT be eligible if...** - You have previously received radiation to the breast area - You are pre-menopausal - Your tumor is not detectable on imaging Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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