Focused Ultrasound for the Complex Patient

This study uses focused ultrasound — sound waves directed at the brain to reduce overactive pain signals — in patients who have chronic back pain, opioid use disorder (dependency on opioid pain medications), and an anxiety disorder all at once. It aims to reduce pain and stress without adding more medications. **You may be eligible if...** - You are aged 18–75 with chronic back pain lasting at least 3 months - You have been diagnosed with opioid use disorder and are in treatment with buprenorphine or methadone - You have a current anxiety disorder (generalized anxiety, PTSD, or social anxiety) - Your pain is rated 4 out of 10 or higher on a standard scale **You may NOT be eligible if...** - You have neuropathic pain (nerve damage-related pain) - You have a substance use disorder other than opioids - You have metal implants in your head or a pacemaker - You are pregnant Talk to your doctor to see if this trial is right for you.