RecruitingPhase 2NCT06454578

Adjuvant Adebrelimab Plus Apatinib for Participants With HCC at High-risk of Recurrence After Curative Resection

An Open-Label, Single Arm Study to Evaluate the Efficacy and Safety of Adebrelimab Plus Apatinib as Adjuvant Therapy in Participants With Hepatocellular Carcinoma at High Risk of Recurrence After Surgical Resection


Sponsor

Qilu Hospital of Shandong University

Enrollment

30 participants

Start Date

Jul 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This is a single-center, single-arm, open-label clinical study to evaluate the efficacy and safety of Adebrelimab plus Apatinib as adjuvant therapy in hepatocellular carcinoma (HCC) participants who are at high risk of recurrence after curative resection.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adebrelimab (an immunotherapy drug) combined with apatinib (a drug that cuts off blood supply to tumors) can prevent liver cancer from coming back after surgery. It focuses on patients with hepatocellular carcinoma (HCC) who have features that make recurrence more likely, such as multiple tumors or vascular invasion. **You may be eligible if...** - You have had liver cancer (hepatocellular carcinoma) removed with curative intent within the past 4–12 weeks - Your tumor had high-risk features for recurrence (e.g., multiple tumors, tumor >5 cm, vascular invasion, poor differentiation, or positive AFP) - Your liver function is adequate (Child-Pugh A or B ≤7 points) - You have not received any prior systemic anti-cancer treatment **You may NOT be eligible if...** - Your cancer was not completely removed or has already spread - You have poor liver function, active viral hepatitis (uncontrolled), or autoimmune hepatitis - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAdebrelimab + Apatinib

the first 6 months or 8 cycles: Adebrelimab 1200 mg, every 3 weeks; Apatinib 250 mg/day Maintenance phase: Adebrelimab 1200 mg, every 3 weeks, Maximum maintenance up to 2 years


Locations(1)

Qilu Hospital of Shandong University

Jinan, Shandong, China

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NCT06454578


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