AV133 Longitudinal Imaging Study in Patients With Early and Prdromal Parkinson's Disease

This study uses a specialized brain imaging scan (AV133 PET scan) to track changes in dopamine-producing cells in people with early or early-warning (prodromal) Parkinson's disease over time. The goal is to better understand how the disease progresses in its earliest stages. **You may be eligible if...** - You are 30 or older with a clinical diagnosis of Parkinson's disease - You were diagnosed within the past 2 years - You have at least two of the key motor symptoms: resting tremor, slowness of movement (bradykinesia), or rigidity - Your disease is at an early stage (Hoehn & Yahr stage I or II) - Your AV133 PET scan suggests reduced dopamine storage in the brain **You may NOT be eligible if...** - Your diagnosis is older than 2 years - Your disease is more advanced (stage III or higher) - Your PET scan does not show the expected dopamine changes Talk to your doctor to see if this trial is right for you.