RecruitingNot ApplicableNCT06457230

Paired-pulse rTMS Treatment for Methamphetamine Use Disorder Based on the mPFC-Cerebellum

Exploration of the Intervention Mechanism and Efficacy of Paired-pulse rTMS Treatment for Methamphetamine Use Disorder Based on the mPFC-Cerebellum

Sponsor

Shanghai Mental Health Center

Enrollment

70 participants

Start Date

Dec 24, 2024

Study Type

INTERVENTIONAL

Conditions

Methamphetamine Use Disorder

Summary

To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired medial prefrontal cortex (mPFC) -cerebellar pulses on methamphetamine use in patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management of addicted patients.

Eligibility

Sex: MALEMin Age: 18 YearsMax Age: 60 Years

Inclusion Criteria6

Primary substance of abuse is methamphetamine.
Meets the DSM-5 diagnostic criteria for severe methamphetamine use disorder (≥6 symptoms present within the past year).
Age: 18-60 years.
Education level of primary school or above, with the ability to comprehend questionnaires and behavioral tasks.
Normal vision and hearing; right-handed.
No prior participation in any TMS-related intervention therapy.

Exclusion Criteria3

Presence of any metallic implants (e.g., dental prostheses, orthodontic braces, bone fixation plates, aneurysm clips, intrauterine devices) or implanted medical devices such as cardiac pacemakers or neurostimulators.
Chronic or severe somatic diseases (e.g., cardiac conditions, uncontrolled hypertension, physical disabilities).
Comorbid psychiatric disorders (e.g., schizophrenia, depressive disorders, anxiety disorders).

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Interventions

DEVICEPaired Associative Stimulation Targeting the Cerebellar-mPFC

The protocol consisted of 180 pulse trains. Each train contained 5 pulse pairs delivered over 1 second, resulting in a stimulation frequency of 5 Hz. Within each pulse pair, the cerebellum was stimulated first, followed by the mPFC after a 6-ms inter-stimulus interval (ISI). In total, 900 pulse pairs were administered, and a complete intervention session lasted 11 minutes and 57 seconds.

DEVICESham Intervention Group

The coil will be placed vertically over the cerebellar and mPFC brain regions, allowing participants to perceive the coil's vibration and sound without receiving effective intervention. All other stimulation parameters are identical to those in the active intervention group.