Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke
High-resolution Functional Imaging of Speech-induced Sensory Modulation
University of Pittsburgh
100 participants
May 27, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Eligibility
Plain Language Summary
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Interventions
Measuring speech-related brain activity using fMRI during a speech listening task.
Measuring speech-related brain activity using fMRI during a silent articulation task.
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
Behavioral measurements of speech during reading passages and words
Measurements of auditory acuity during listening tasks.
Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Locations(1)
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NCT06458153