RecruitingNCT06458504

Viral Infection of HSPC Impacts Hematopoiesis

Virus-induced Immunosuppression Via Infection of Hematopoietic Progenitors

Sponsor

Assistance Publique - Hôpitaux de Paris

Enrollment

45 participants

Start Date

Oct 25, 2024

Study Type

OBSERVATIONAL

Conditions

HIV-1

Summary

We propose to demonstrate that HIV-1 and SARS-CoV-2 are capable of targeting long-lived HSPC with self-renewal capacities. These progenitors, thus transformed into host cells, can give rise to a durable source of infected cells with an impact on hematopoiesis.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

HIV patients :
HIV-positive patients with a negative or positive viral load.
managed at Ambroise Paré Hospital.
patients with a bone marrow biopsy or myelogram performed as part of their care.
Healthy subjects without HIV - patients with a BM biopsy or myelogram performed as part of their care for a suspected hematological pathology.
Management at Ambroise Paré Hospital.