Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies

This is a Phase 1 study testing a new experimental drug called DSB2455 in people with advanced solid tumors (cancers that have spread or cannot be removed by surgery). The goal is to find out how safe the drug is and what doses the body can tolerate. **You may be eligible if...** - You are 18 or older - You have advanced cancer with measurable disease on standard imaging - Your functional status is good (ECOG 0–1) and you have a life expectancy of at least 12 weeks - You can provide a tissue sample from your tumor (either from a prior biopsy or a new biopsy) - You are willing to follow the study schedule **You may NOT be eligible if...** - You do not have measurable disease - Your performance status or organ function does not meet the required levels - You cannot provide a tumor tissue sample - You have other serious medical conditions that make participation unsafe Talk to your doctor to see if this trial is right for you.