Amygdala MRI-TIS for Depression

This study tests a non-invasive brain stimulation technique called Temporal Interference Stimulation (TIS) targeting the amygdala (a key emotional brain region) as a treatment for people with depression who have not responded well to standard antidepressant medications. **You may be eligible if...** - You are between 18 and 65 years old - You have been diagnosed with depression by a study physician - Your depression score on a standard scale (HAMD-17) is 17 or higher - You have not changed your antidepressant medication in the past 30 days and agree to keep it stable during the study **You may NOT be eligible if...** - You have a history of epilepsy or seizures - You have metal implants in your head or a cardiac metal implant - You have had brain surgery or significant head trauma - You have recently received electroconvulsive therapy (ECT) or similar physical brain treatments - You have other psychiatric or neurological conditions that could interfere with results Talk to your doctor to see if this trial is right for you.