Packed Red Blood Cell Transfusion During Cardiac Arrest
A Single-center, Randomized, Placebo Controlled Pilot Study of Packed Red Blood Cell Transfusion During Prolonged Adult In-hospital Cardiac Arrest
NYU Langone Health
30 participants
Mar 25, 2025
INTERVENTIONAL
Conditions
Summary
The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA). The primary objective is to assess the feasibility of PRBC transfusion during cardiac CA to help optimize the methods required to augment cerebral and other vital organ oxygen delivery during cardiopulmonary resuscitation (CPR). The secondary objectives are to assess the effect of PRBC transfusion during prolonged cardiac arrests on cerebral oxygenation, end tidal carbon dioxide (ETCO2), return of spontaneous circulation (ROSC), survival to discharge, biomarkers of neural injury and inflammation, and neurological outcomes at hospital discharge, 30 days post-CA, and 90 days post-CA.
Eligibility
Inclusion Criteria2
- Adult patients, age ≥18 and <85 years
- Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes
Exclusion Criteria13
- Age <18 years old
- Age > 85 years old
- Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate)
- Patients admitted to the hospital with a cardiac arrest arising from trauma
- Patients who achieve return of spontaneous circulation within 10 minutes of CPR
- Inability to start study product administration within 20 minutes of cardiac arrest onset
- Prisoners
- Women who are known to be pregnant
- Patients with a history of RBC antibodies or positive antibody screen prior to enrollment in the study, unless previously cross-matched units are available for transfusion.
- Patients with ultrasound evidence of right ventricular dilatation at time of CA
- Patients with known prior objection to receipt of blood products.
- Patients for whom administration of additional fluid volume is contraindicated (as determined by physician responsible for care)
- Physician objection based on concern that intervention would interfere with patient care plan
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Interventions
500 mL of packed red blood cells administered intravenously 10-20 minutes after CA onset, provided Return of Spontaneous Circulation (ROSC) has not been achieved.
1000 mL of packed red blood cells administered intravenously 10-20 minutes after CA onset, provided Return of Spontaneous Circulation (ROSC) has not been achieved.
Control subjects will receive 500mL of normal saline intravenously.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06462027