RecruitingPhase 4NCT06462469

Study of Efficacy and Safety of Ruxolitinib in Patients With Grade II to IV Steroid-refractory Acute Graft vs. Host Disease

A Single-arm, Multi-center Study of Ruxolitinib for the Treatment of Chinese Patients With Grade II-IV Corticosteroid-refractory Acute Graft Versus Host Disease


Sponsor

Novartis Pharmaceuticals

Enrollment

36 participants

Start Date

Jul 4, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to assess the efficacy and safety of ruxolitinib therapy in Chinese adults and adolescents (≥ 12 years old) with Grade II-IV steroid-refractory acute graft versus host disease (SR-aGvHD).


Eligibility

Min Age: 12 YearsMax Age: 100 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Ruxolitinib for people with steroid-refractory acute graft versus host disease. The study is currently recruiting participants at 17 locations. People eligible for this study include aged 12 Years to 100 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGRuxolitinib

Ruxolitinib is taken orally daily at 10 mg BID, given as two 5-mg tablets.


Locations(17)

Novartis Investigative Site

Guangzhou, Guangdong, China

Novartis Investigative Site

Guangzhou, Guangdong, China

Novartis Investigative Site

Zhengzhou, Henan, China

Novartis Investigative Site

Wuhan, Hubei, China

Novartis Investigative Site

Changchun, Jilin, China

Novartis Investigative Site

Xian, Shanxi, China

Novartis Investigative Site

Chengdu, Sichuan, China

Novartis Investigative Site

Hangzhou, Zhejiang, China

Novartis Investigative Site

Beijing, China

Novartis Investigative Site

Beijing, China

Novartis Investigative Site

Beijing, China

Novartis Investigative Site

Beijing, China

Novartis Investigative Site

Dalian, China

Novartis Investigative Site

Fuzhou, China

Novartis Investigative Site

Shanghai, China

Novartis Investigative Site

Taian, China

Novartis Investigative Site

Tianjin, China

View Full Details on ClinicalTrials.gov

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NCT06462469


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