Development of Electroencephalography (EEG) and Magnetoencephalography (MEG) Source Reconstruction With Fast Multipole Method
Worcester Polytechnic Institute
30 participants
Jan 1, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to learn if an advanced 256 dry electrode EEG cap augmented with MEG readings and coupled with a new high-resolution fast brain modeling software gives a better EEG and MEG source localization in real time. The main questions it aims to answer are: * Does the testbed better localize brain sources for finger movement? * Does the testbed better localize brain sources for median nerve stimulation? * Does the testbed better localize brain sources for speech processing? * Researchers will compare the predicted cortical locations with MEG data and known anatomical locations of the neuronal generators. Participants will: * Undergo Magnetic Resonance Imaging (MRI) scans for brain and head model creation * Undergo three different EEG tests * Undergo three different MEG tests
Eligibility
Inclusion Criteria3
- Age at least 18 and less than 66 years
- Normal hearing and (corrected) vision
- Able to understand and give informed consent
Exclusion Criteria13
- Cardiac pacemaker or pacemaker wires; neurostimulators; implanted pumps
- Metal in the body (rods, plates, screws, shrapnel, dentures, IUD) or metallic particles in the eye
- Surgical clips in the head or previous neurosurgery
- Any magnetic particles in the body
- Cochlear implants
- Prosthetic heart valves
- History of skull injury or defects
- Significant claustrophobia; Ménière's disease
- Pregnancy, breast feeding
- Neurological or psychiatric diagnoses or medications influencing brain function
- Current substance abuse (exception: concurrent nicotine use is allowed)
- Failure to perform the behavioral tasks or psychological evaluation tests
- Prisoners
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Interventions
The volunteer is tapping with his/her right hand index finger.
Electrical pulses are applied at the wrist to the median nerve.
German sentences are played to the volunteers and the volunteers have to fulfill a semantic task.
Locations(2)
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NCT06471244