Unraveling the Genetic Basis of Nicotine Addiction for Novel Therapeutic Strategies
Exploring the Genetic and Molecular Underpinning of Nicotine Addiction for the Development of New Therapeutic Strategies
University of Cyprus
200 participants
Nov 1, 2023
OBSERVATIONAL
Conditions
Summary
This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets. The project will involve drug repurposing using Mendelian Randomization, a smoking cessation intervention, and the analysis of methylation status in participants undergoing nicotine withdrawal.
Eligibility
Inclusion Criteria4
- Adults aged 18-60 years old
- Current daily cigarette smoker
- Able to understand study procedures and provide informed consent
- For females, non-pregnant and non-lactating
Exclusion Criteria5
- Presence of significant uncontrolled medical conditions (e.g. cardiovascular disease, respiratory disorders, cancer) that could affect smoking behaviors or study participation
- Presence of major uncontrolled psychiatric disorders (e.g. schizophrenia, bipolar disorder, severe depression)
- Current substance use disorder (except nicotine dependence)
- Taking medications that could significantly interfere with study objectives (e.g. medications for smoking cessation)
- Significant cognitive impairment that precludes ability to complete study procedures
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Interventions
Participants will enter a 6-week (once weekly) self-delivered computerized intervention program called Flexiquit. Developed and validated by Clinical Psychologists of the Department of Psychology at the University of Cyprus, Flexiquit is an avatar-led app designed to support smoking cessation. It aims to assist with abstinence and monitor participants' progress through personalized modules and assessments.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06471387