RecruitingNot ApplicableNCT06472986

Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation After Spinal Cord Injury (ABT-TCSCS)

Feasibility and Efficacy of Activity-Based Therapy and Transcutaneous Spinal Cord Stimulation for Neurorestoration of Upper Limbs After Cervical Spinal Cord Injury

Sponsor

University Health Network, Toronto

Enrollment

24 participants

Start Date

Oct 7, 2022

Study Type

INTERVENTIONAL

Conditions

Spinal Cord Injuries Spinal Cord Injury Cervical

Summary

The ABT-TCSCS study investigates how feasible and beneficial are activity-based therapy and transcutaneous spinal cord stimulation on improving of arm and hand recovery after cervical spinal cord injury.

Eligibility

Min Age: 18 Years

Inclusion Criteria6

Individuals with chronic traumatic and non-traumatic cervical SCI (ASIA classification A-incomplete\*\*, B, C, D) between C1-C8
Adults more than 18 years old
At least 6 months post-spinal cord injury
A score of 2 - 15 on the upper extremity motor score of the ISNCSCI
A score between 5 - 40 on GRASSP Version 1 Strength on at least one side
Individuals who are medically stable

Exclusion Criteria4

Individuals with any other upper extremity deficit
Unable to provide informed consent
Unable to participate in an intensive rehabilitation outpatient program
Spasticity that limits the range of motion greater than 50% for the elbow or wrist

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Interventions

OTHERActivity-based therapy and transcutaneous spinal cord stimulation

Activity Based Therapy (ABT) is a method of neuro-rehabilitation that incorporates a high intensity, long duration and effortful engagement from the individual receiving therapy, to garner improvements in sensory and motor function. The ABT constitutes 4 types of exercises including: cardio-fitness, resistance, postural/weightbearing and functional exercises. TransCutaneous Spinal Cord Stimulation (TCSCS) stimulates spinal networks in the cervical region to neuro-modulate the descending motor commands/motor intentions from the brain, which control the muscles. In tCSCS, electrical stimulation is delivered at a frequency of 30-50Hz at 500-1000µs between C3-C7. 12 sessions of ABT (4 weeks), followed by 28 sessions of ABT-TCSCS (7 weeks). Each session will last 1 hour and delivered 3 times per week.