The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD

This study is comparing treatment options for people with moderate COPD (a chronic lung disease that makes breathing difficult). Specifically, it is looking at whether a triple inhaler combination (three different types of bronchodilators in one device) works better than using one or two inhalers — to see which approach best controls symptoms and prevents flare-ups. **You may be eligible if...** - You have COPD at a moderate level (classified as GOLD B) - You have had no more than one COPD flare-up in the past year - You are currently using a LAMA inhaler, a LAMA/LABA combination, or short-acting inhalers - You are able to give informed consent **You may NOT be eligible if...** - You have active or past tuberculosis, lung cancer, bronchiectasis, lung fibrosis, or other serious lung or heart diseases - You are on long-term immune-suppressing drugs or systemic steroids - You are already using triple inhaler therapy (ICS/LABA/LAMA) - You are in a terminal stage of illness Talk to your doctor to see if this trial is right for you.