A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors

Exclusion Criteria22

• Stage 1 EGFR-sensitive mutant non-small cell lung cancer patients with systemic chemotherapy; Stage 2 patients who had received previous systemic therapy;
• In the second stage queue one signed informed consent before gene sequencing report suggests patients such as mutation of ALK fusion;
• Anti-tumor therapy such as chemotherapy or biological therapy has been used within 4 weeks or 5 half-lives before the first dose; Mitomycin and nitrosoureas were administered within 6 weeks before the first dose; Fluorouracil class oral drugs, etc.;
• Serious heart disease;
• Long QT, complete left bundle branch block, III degree atrioventricular block; Serious arrhythmia;
• Active autoimmune and inflammatory diseases;
• Before the first delivery within 5 years diagnosed as other malignant tumor;
• Two antihypertensive drugs poorly controlled hypertension;
• Patients with poor glycemic control;
• With a history of ILD, current ILD or suspected suffering from such diseases during screening;
• Complicated with pulmonary diseases leading to severe respiratory function impairment;
• There is a lot of serous cavity effusion, or have a serous cavity effusion and has symptoms, or poorly controlled serous cavity effusion patients;
• Imaging studies suggest tumor has violated or package around the chest, neck, pharyngeal large blood vessels;
• Unstable thrombotic events requiring therapeutic intervention within 6 months before screening; Infusion-related thrombosis was excluded;
• Active central nervous system of patients;
• For restructuring or human mouse chimeric antibody on study of humanized anti-platelet antibody has a history of allergies or allergic to BL - B01D1 any supplementary material composition of patients;
• Before transplant or allogeneic hematopoietic stem cell transplantation (Allo - HSCT);
• Human immunodeficiency virus antibody positive, active tuberculosis, active hepatitis B virus infection or active hepatitis C virus infection;
• Active infection requiring systemic therapy;
• Subjects with clinically significant bleeding or obvious bleeding tendency within 4 weeks before signing the informed consent;
• Had participated in another clinical trial within 4 weeks before the first dose;
• Other conditions for trial participation were not considered appropriate by the investigator.