Predicting Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma

This study is analyzing tissue samples from patients who had surgery for esophageal squamous cell carcinoma (ESCC) — a type of cancer in the food pipe — to try to predict which patients are most likely to have their cancer return after surgery. Researchers want to identify biological markers that could help doctors make better decisions about follow-up care. **You may be eligible if...** - You have been diagnosed with esophageal squamous cell carcinoma confirmed by tissue biopsy - You have already had complete surgical removal of the tumor with full lymph node dissection, without chemotherapy or radiation before or after surgery - Tissue samples from your surgery are still available - You have been followed up for at least 2 years after surgery **You may NOT be eligible if...** - Your medical information from the 2 years after surgery is incomplete - You had multiple cancers at the same time Talk to your doctor to see if this trial is right for you.