RecruitingNCT06477861

The Role of Elastic Power in Predicting the Severity and Mortality in Adult Patients With ARDS Due to Pneumonia

The Role of Elastic Power in Predicting the Severity and Mortality in Adult Patients With Acute Respiratory Distress Syndrome Secondary to Pneumonia


Sponsor

Benha University

Enrollment

70 participants

Start Date

Jan 24, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

the role of elastic power in the prediction of severity and mortality in adults with ARDS secondary to pneumonia


Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria6

  • Age from 18 to 65 years (male or female). Patients fulfilling criteria of ARDS as per Berline definition who will be admitted to ICU , intubated and MV more than 48 hours will be included in this study.
  • Fulfillment of Criteria of readiness for ARDS as per Berline definition :
  • an acute onset (<1 week of a known clinical insult or new or worsening respiratory symptoms),
  • respiratory failure not primarily due to hydrostatic edema,
  • bilateral opacities on a chest radiograph (not fully explained by effusions, lobar or lung collapse, or nodules), and
  • <300 mmHg of the ratio of arterial partial pressure of oxygen (PaO2) to the fraction of inspired oxygen (FiO2) (PaO2/FiO2) with 5 cm H2O of positive end-expiratory pressure (PEEP) or continuous positive airway pressure. To facilitate the estimation of the ARDS prognosis, the Berline definition classifies the severity of ARDS into 3 categories: mild (200 mmHg < PaO2/FiO2 < 300 mmHg), moderate (100 mm Hg < PaO2/FiO2 <200 mmHg), and severe (PaO2/FiO2 < 100 mmHg).

Exclusion Criteria6

  • Non intubated ICU admissions
  • Non-invasive ventilated patients.
  • Age less than 18 years or more than 65 years of age
  • Open chest wall trauma.
  • Patient requiring Extra Corporal Membrane Oxygenator
  • Patients with increased intrabdominal pressure interfering with mechanical ventilator parameters measurements

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Interventions

OTHERcalculation of the elastic power of the lung in case of the ARDS and corolating with the severity index of Berline definition of ARDS in respect to mortality and severity

calculation of variables of the elastic power of the lung from the lung pressures on the ventilator : Elastic power = 0.098 \* tidal volume \* respiratory rate \* 1/2(PEEP+Pplat)


Locations(1)

Banha University Hospital

Banhā, Al Qalubeyah, Egypt

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NCT06477861


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