RecruitingNCT06479941

Antibiotic Exposure During Pregnancy Affects Infant Gut Microbiota


Sponsor

Peking University People's Hospital

Enrollment

450 participants

Start Date

Jun 25, 2023

Study Type

OBSERVATIONAL

Conditions

Summary

Based on a prospective birth cohort, the investigators will collect biological samples from participants including pregnant women and newborns, to measure the gut microbial diversity and metabolites of newborns. These results systematically evaluate the effects of antibiotic exposure on the structure and function of gut microbiota. The project can reveal the effects of antibiotic exposure on the growth and development of gut microbiota in early life.


Eligibility

Min Age: 1 DayMax Age: 12 Months

Inclusion Criteria8

  • Pregnant woman
  • aged 20-40 years old
  • natural conception
  • single pregnancy
  • gestational age ≥36 weeks
  • Newborn
  • normal Apgar score
  • no serious congenital diseases

Exclusion Criteria1

  • \-

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Interventions

OTHERantibiotic treatment

AT: Mother-infant cohort with antibiotic treatment group CS: Mother-infant cohort (Prophylactic antibiotics therapy) ND: Mother-infant cohort (Natural delivery)


Locations(1)

The Peking University People's Hospital

Beijing, China

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NCT06479941