Efficacy of Organoid-Based Drug Screening to Guide Treatment for Locally Advanced Thyroid Cancer

This study is testing whether growing "mini-tumors" (organoids) from a patient's own thyroid cancer cells in a lab can help doctors find the most effective drug before treatment begins — essentially personalizing cancer therapy. This is aimed at patients with locally advanced or recurring thyroid cancer where surgery may not be fully curative. **You may be eligible if...** - You are an adult with locally advanced, persistent, or recurrent thyroid cancer (including papillary, follicular, medullary, poorly differentiated, or anaplastic types) - Your cancer shows signs of invading nearby structures (such as vocal cord paralysis or involvement of the trachea or major blood vessels) - Your surgical team believes there is a risk of incomplete removal **You may NOT be eligible if...** - Your cancer is not one of the types listed above - Your disease is not locally advanced or has been fully removed without risk of residual disease Talk to your doctor to see if this trial is right for you.