RecruitingNot ApplicableNCT06482138
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Dysfunction of Olfaction After SARS-CoV-2 Infection: Morphological and Histomolecular Investigation of Olfactory Cleft Biopsies and Cytobrushes
Sponsor
Universitaire Ziekenhuizen KU Leuven
Enrollment
240 participants
Start Date
Jan 24, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function. The investigators plan to collect olfactory cleft biopsies and cytobrushes in COVID-19 patients and controls.
Eligibility
Min Age: 18 YearsMax Age: 70 Years
Inclusion Criteria2
- Olfactory Dysfunction group: Presence of evident OD (Parosmia, Threshold-Discrimination-Identification (TDI)-score ≤24, Subjective abnormal quantitative olfactory function; measured by a visual analogue score (VAS) of smell impairment ≥5/10
- Control group: No OD (TDI-score \>30.5.)
Exclusion Criteria3
- Presence of concomitant nasal mucosal pathology that might affect olfactory function or bias the study investigations
- Use of anticoagulation therapy
- Allergy to local anesthetics
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Interventions
PROCEDUREBiopsy and Cytobrush
Collection of olfactory cleft biopsies and cytobrushes
Locations(7)
View Full Details on ClinicalTrials.gov
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NCT06482138
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