A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

This trial is studying whether radiation therapy after surgery is beneficial for people with early-stage squamous cell carcinoma of the tongue (mouth cancer) who have certain higher-risk features in their removed tumor, but do not have the most severe risk factors that typically require post-surgical radiation. **You may be eligible if...** - You are 18 or older - You had surgery that removed all visible cancer in your mouth/tongue - Your pathology report shows certain risk features such as lymphovascular invasion, tumor depth between 4–10mm, or 1-2 positive lymph nodes - Your surgical margins (distance from the cut edge to the cancer) are adequate (at least 3mm) **You may NOT be eligible if...** - Your cancer involves 3 or more lymph nodes - Cancer cells were found at or very close to the surgical edge (positive margins) - Cancer has broken out of a lymph node capsule (extracapsular extension) - You have extensive nerve invasion by the tumor - You have a serious autoimmune condition - You had a prior or simultaneous cancer that poses a similar risk of death Talk to your doctor to see if this trial is right for you.