RecruitingNot ApplicableNCT06489483

Action Regulation Behavioral

Revealing the Action Regulation Mechanisms in the Human Brain


Sponsor

University of Texas Southwestern Medical Center

Enrollment

50 participants

Start Date

Apr 24, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Parkinson's disease (PD) is a neurodegenerative disorder involving a part of the brain that is responsible for motor control, which not only results in changes or disruptions in movement, but also cognitive dysfunctions. Given that the decline of muscle control such as tremors, with difficulty walking or the ability to switch tasks once in movement, greatly affects the quality of daily life. Action regulation is a critical executive function (cognitive control over behavior), which includes actions such as suppressing activity when selecting between options, making decisions about stopping unwanted or inappropriate actions, and switching to new actions in response to environmental changes. Parkinson's disease (PD) has been shown to disrupt action inhibition which can be considered a measure to the progression of PD. The purpose of this research study is to better understand the mechanism of action regulations in PD patients and how action regulations in PD can be improved using dopaminergic treatment, which is a drug that either releases or involves dopamine, which is a neurotransmitter involved in sending signals to nerve cells. You are asked to participate in this research study because you are receiving a dopaminergic medication for treatment of your Parkinson's disease. There is currently no theory that integrates the mechanisms of action regulation into a unified framework, which this study aims to address. The researchers hope to learn more about the mechanisms of action regulation in PD patients and to help decrease action regulation disruptions in PD patients. This study will help characterize the motor behavior of PD patients.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is examining how the brain controls voluntary movement in people with Parkinson's disease compared to healthy volunteers, using behavioral tasks (no surgery or medication changes involved). Researchers want to better understand the role of action control and decision-making in Parkinson's. **You may be eligible if...** - You have a diagnosis of Parkinson's disease confirmed by a movement disorder specialist - Your Parkinson's responds well to levodopa medication (with clear 'on' periods) - You are willing and able to complete behavioral tasks for up to 3.5 hours - You have no significant vision or hearing problems **You may NOT be eligible if...** - You have a different type of Parkinsonism caused by stroke or another brain condition - You have dementia or significant memory/thinking problems - You have had deep brain stimulation surgery Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALAction Regulation Movement Task

A joystick is utilized to trace the movement of a visual stimulus on a computer screen. In stop signal task, the subjects are required to move a reference dot to reach to a target dot by controlling a joystick and stop their movements when the target turns red. During the switch task, subjects will be required to switch their joystick movement trajectory when the target location is switched to one of the other target locations.


Locations(1)

University of Texas Southwestern Medical Center

Dallas, Texas, United States

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NCT06489483


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