RecruitingNCT06490029

Diagnostic of Various Ototoxicity Induced by Cancer Treatment

Evaluation of Hidden Hearing Loss and Vestibular Damage Induced by Anti-cancer Treatments


Sponsor

Direction Centrale du Service de Santé des Armées

Enrollment

540 participants

Start Date

Jun 19, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

• Visit the clinic once every 2 weeks for checkups and tests The goal of this clinical trial is to learn if systematic hearing tests (eg fonctional assesment, electrophysiology and seric biomarkers) can diagnose hidden hearing loss or vestibular troubles in a population of patients treated for cancer; population study will include different population in terms of sex/gender, age, medical condition (cancer patients treated with surgery alone and/or radiotherapy and/or chemotherapy, and healthy volunteers). The main question it aims to answer is: • To assess the ototoxicity of anticancer drugs using a combination of auditory functional tests (including speech audiometry in noise), vestibular test , plasmatic samples and electrophysiological measures. Participants will be studied: Either only after exposition (single visit) Or before, during and after the exposition to potential otototoxic agents with a 4 times Visit the clinic checkups and tests (one before, two while ongoing potential ototoxic agents and 1 post exposition) Participants will complete questionnaires, undergo audiometric and electrophysiological tests, and their routine biomedical data will be studied, without any modification of the routine care (planned cancer treatment)


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Auditory, vestibular and electrophysiological investigations and Biologic investigations; seric proteins for people with ototoxicity, drug-induced. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTAuditory, vestibular and electrophysiological investigations

otoacoustic emissions, electrocochleography, vocal audiometry in noise and high-frequency tonal audiometry, impedancemetry

DIAGNOSTIC_TESTBiologic investigations; seric proteins

seric proteins


Locations(1)

HIA Bégin

Paris, France

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NCT06490029


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