RecruitingPhase 1Phase 2NCT06490731
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients With Intraabdominal Sepsis: A Randomized Controlled Study
Sponsor
New Valley University
Enrollment
2 participants
Start Date
Apr 1, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
Inflammatory response and hemodynamic response in patients with intraabdominal sepsis and Effects of Dexmedetomidine versus ketamine on it .
Eligibility
Min Age: 18 YearsMax Age: 70 Years
Inclusion Criteria2
- Adult patients admitted to ICU after ileus surgery (perforated viscus, infarcted bowel, strangulated hernia, anastomotic leakage, diverticulitis, and intestinal obstruction), and who will be expected to require postoperative sedation and ventilation.
- Abdominal sepsis was determined as organ dysfunction with a substantial change in overall SOFA score (2) ≥ 2 points because of intra-abdominal sepsis.
Exclusion Criteria7
- Known allergy to ketamine, dexmedetomidine,
- Confirmed pregnancy,
- Heart failure (class 3 or 4 of the New York Heart Association),
- Renal failure (RIFLE classification),
- Liver failure (manifested by serum total protein concentration <3 g/dl and total bilirubin >5 mg/dl)
- Known or suspected brain death.
- Patients who receive neuromuscular blockers during the first 48 hours of ICU admission will also be excluded.
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Interventions
DRUGDexmedetomidine
Patients will receive dexmedetomidine
DRUGKetamine
patients Will receive ketamine
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06490731