RecruitingPhase 1NCT06491225

Autologous Tumor-Infiltrating Lymphocyte (GTE-001 Injection ) for Treatment of Patients with Advanced Lung Adenocarcinoma

A Phase I, Open Label, Multicenter Study Evaluating the Safety and Efficacy of Autologous Tumor-Infiltrating Lymphocyte (GTE-001 Injection ) for Treatment of Patients with Advanced Lung Adenocarcinoma


Sponsor

Grit Biotechnology

Enrollment

12 participants

Start Date

Jul 18, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study is a Multiple centers, open design aimed at evaluating the safety,efficacy and Production feasibility of Autologous Tumor-Infiltrating Lymphocyte (GTE-001 injection ) for treatment of patients with Advanced lung adenocarcinoma,And evaluate potential biomarkers related to GTE-001 activity.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a personalized immune cell therapy called GTE-001 — made from the patient's own tumor-infiltrating lymphocytes (immune cells extracted from their tumor) — in people with advanced lung adenocarcinoma (a type of non-small cell lung cancer) that has progressed despite prior treatment. **You may be eligible if...** - You are 18 or older with confirmed advanced lung adenocarcinoma - Your cancer has progressed after first-line chemotherapy or after recurrence - Your general health is good enough to tolerate the treatment (ECOG 0–1) - You have at least one measurable tumor and expected survival of at least 3 months **You may NOT be eligible if...** - You have previously received engineered cell therapy (like CAR-T cells) or an organ transplant - You have active autoimmune disease - You have brain metastases that are untreated or symptomatic - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALGTE001 injection

GTE-001 injection to treat Advanced lung adenocarcinoma


Locations(1)

Beijing GoBroad Hospital

Beijing, Beijing Municipality, China

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NCT06491225