RecruitingNCT06491862
RACE-2L: Real-World Assessment of Clinical Practice and Outcomes in Non-squamous NSCLC After Failure of Platinum-based Chemotherapy in Brazil
RACE-2L: Real-World Assessment of Clinical Practice and Outcomes in Non-squamous Non-Small Cell Lung Cancer After Failure of Platinum-based Chemotherapy in Brazil
Sponsor
AstraZeneca
Enrollment
250 participants
Start Date
Jul 25, 2024
Study Type
OBSERVATIONAL
Summary
The study will be implemented as a retrospective, noninterventional medical record review of patients from routine practice settings who have been diagnosed with a/m non-squamous NSCLC with or without AGA and received at least 1 line of systemic treatment after failing PTC between January 2017 and December 2024.
Eligibility
Min Age: 18 Years
Inclusion Criteria5
- Confirmed diagnosis of patients with non-squamous NSCLC stage IIIB/IIIC not eligible for curative-intent therapies or stage IV/M1 (a/m NSCLC) with or without actionable genomic mutations (i.e., EGFR, ALK, ROS1, NTRK, BRAF, MET exon 14 skipping, RET, HER-2)
- Aged at least 18 years at first diagnosis of a/m NSCLC
- For the AGA subgroup, having received platinum-based chemotherapy, having received at least one target approved therapy.
- For the non\_AGA subgroup,should have received either sequential or concurrent use of ICI and PTC)
- Patient must have received at least line of therapy of an active agent after failing PTC.
Exclusion Criteria2
- Patients with evidence of other primary malignancies (apart from basal cell carcinoma and melanoma) within 1 year prior to the index date will be excluded from both the study cohorts.
- Patients who participated in an investigational clinical trial for the treatment of any cancer, including NSCLC, or any early access program from 2018 onward.
Locations(11)
View Full Details on ClinicalTrials.gov
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NCT06491862