RecruitingNot ApplicableNCT06492200

Impact of a High-fiber Diet on the Microbiome and Disease Activity in Patients With Rheumatoid Arthritis

Einfluss Ballaststoffreicher Ernährung Auf Das Mikrobiom Und Die Krankheitsaktivität Von Patientinnen Und Patienten Mit Rheumatoider Arthritis


Sponsor

Wuerzburg University Hospital

Enrollment

52 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to learn if increasing dietary fiber can improve the gut microbiome and reduce disease activity in adults with rheumatoid arthritis (RA). The main questions it aims to answer are: * Can a higher fiber diet improve gut bacteria and produce beneficial short-chain fatty acids (SCFAs)? * Does a higher fiber diet reduce RA symptoms and help with weight loss? Researchers will compare two groups: one group will receive dietary counseling and take 10 grams of psyllium husk daily, while the other group will continue their usual diet. Participants will: * Complete dietary questionnaires at the start, 6 months, and 12 months. * Provide stool samples for gut bacteria and SCFA analysis. * Have their RA activity and body weight monitored regularly. * Receive regular phone calls to support the dietary changes. The study will involve adults with diagnosed RA who can provide informed consent and meet other inclusion criteria.


Eligibility

Min Age: 18 YearsMax Age: 99 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a high-fiber diet changes the gut microbiome (the community of bacteria in the gut) and reduces disease activity in people with rheumatoid arthritis (RA), an autoimmune condition that causes joint inflammation. Researchers believe gut bacteria may play a role in immune regulation. **You may be eligible if...** - You are over 18 with a confirmed diagnosis of rheumatoid arthritis - You understand the scope of the study and consent in writing to participate **You may NOT be eligible if...** - You have inflammatory bowel disease (like Crohn's or ulcerative colitis) - You have liver cirrhosis or a history of bowel obstruction - You have a stoma (surgically altered bowel) - You have taken antibiotics in the past 3 months - You have been using psyllium husk supplements in the past 4 weeks - You have insufficient German language skills Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERPsyllium husks

Patients in the intervention group will receive nutritional counseling and will be asked to take 10g (one tablespoon) of ground psyllium husks daily to significantly increase the fiber content of their diet.


Locations(1)

University Würzburg

Würzburg, Germany

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NCT06492200


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