RecruitingNot ApplicableNCT06492200

Impact of a High-fiber Diet on the Microbiome and Disease Activity in Patients With Rheumatoid Arthritis

Einfluss Ballaststoffreicher Ernährung Auf Das Mikrobiom Und Die Krankheitsaktivität Von Patientinnen Und Patienten Mit Rheumatoider Arthritis

Sponsor

Wuerzburg University Hospital

Enrollment

52 participants

Start Date

Jun 1, 2024

Study Type

INTERVENTIONAL

Conditions

Arthritis, Rheumatoid

Summary

The goal of this clinical trial is to learn if increasing dietary fiber can improve the gut microbiome and reduce disease activity in adults with rheumatoid arthritis (RA). The main questions it aims to answer are: * Can a higher fiber diet improve gut bacteria and produce beneficial short-chain fatty acids (SCFAs)? * Does a higher fiber diet reduce RA symptoms and help with weight loss? Researchers will compare two groups: one group will receive dietary counseling and take 10 grams of psyllium husk daily, while the other group will continue their usual diet. Participants will: * Complete dietary questionnaires at the start, 6 months, and 12 months. * Provide stool samples for gut bacteria and SCFA analysis. * Have their RA activity and body weight monitored regularly. * Receive regular phone calls to support the dietary changes. The study will involve adults with diagnosed RA who can provide informed consent and meet other inclusion criteria.

Eligibility

Min Age: 18 YearsMax Age: 99 Years

Inclusion Criteria3

Patients over 18 years old
Diagnosis of Rheumatoid Arthritis according to the ACR criteria of 2010
The patient can understand the scope of the study and consents in writing to participate.

Exclusion Criteria9

Age under 18
Lack of consent capability
Insufficient knowledge of the German language
Chronic inflammatory bowel disease
Liver cirrhosis
History of mechanical ileus
Patients with altered gastrointestinal passage (e.g., stoma patients)
Use of antibiotics within the past three months
Use of ground psyllium husks four weeks prior to study inclusion

Interventions

OTHERPsyllium husks

Patients in the intervention group will receive nutritional counseling and will be asked to take 10g (one tablespoon) of ground psyllium husks daily to significantly increase the fiber content of their diet.