RecruitingNot ApplicableNCT06495190

Cognition, Flavonoids, Exercise, Gut Microbiome

Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome


Sponsor

Appalachian State University

Enrollment

240 participants

Start Date

Jan 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.


Eligibility

Min Age: 65 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This trial is studying whether consuming flavonoid-rich foods (plant compounds found in berries, cocoa, and tea) combined with a 12-week exercise program can improve memory and gut health in older adults with mild cognitive decline. **You may be eligible if...** - You are 65–85 years old in good general health - You are a non-smoker - You show mild cognitive decline (MoCA score between 24.1 and 25.2) - You are currently physically inactive (exercising less than 150 minutes per week) - You are willing to be randomized to a dietary or exercise group **You may NOT be eligible if...** - You have a diagnosis of dementia or significant cognitive impairment - You are already physically active - You have a condition that prevents you from doing light to moderate exercise - You are currently taking medications or supplements that could interact with flavonoids Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DIETARY_SUPPLEMENTBlueberry

50 g/d blueberry powder supplement

BEHAVIORALWalking

Five 45-min walking sessions per week

DIETARY_SUPPLEMENTPlacebo

50 g/d placebo powder supplement

BEHAVIORALStretching

Five 45-min stretching sessions per week


Locations(1)

Appalachian State University Human Performance Lab, North Carolina Research Campus

Kannapolis, North Carolina, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06495190


Related Trials